Pharmacokinetics
Onset time: 30 seconds        Offset time: 3-7 minuntes
Propofol may also be used by continuous infusion to maintain anaesthesia.
Metabolism: Two pathways: conjugated in the liver to the glucuronide and hydroxylated to the quinol, which is subsequently glucuronidated.

Pharmacodynamics
CNS: Hypnosis.

Common side-effects
CVS: Direct myocardial depression and reduction in SVR causing hypotension, but little change in heart rate (bradycardia may occur) and reduction in cardiac output (CO). Use with caution in the hypovolaemic patient.
RS: Dose-dependent respiratory depression. Upper airway reflexes obtunded more than for thiopental, allowing earlier placement of a laryngeal mask.

Other effects
Pain on injection, which can be reduced by the use of lidocaine.
Nausea and vomiting is much less likely after propofol than other agents.
Hypersensitivity reactions: Approximately 1 in 100 000.

Relative contraindication to use
Not licensed for children under three.